Sinopsis
Tercera entrega de las aventuras del joven Peter Parker. Parece que Parker ha conseguido por fin el equilibrio entre su devoción por Mary Jane y sus deberes como superhéroe. Pero, de repente, su traje cambia volviéndose negro y aumentando sus poderes; también Peter se transforma, sacando el lado más oscuro y vengativo de su personalidad. Bajo la influencia de este nuevo traje, Peter deja de proteger a la gente que realmente lo quiere y se preocupa por él. En estas circunstancias, no tiene más remedio que elegir entre disfrutar del tentador poder del nuevo traje o seguir siendo el compasivo héroe de antes. Mientras tanto, dos temibles enemigos, Venom y el Hombre de Arena, utilizarán sus poderes para calmar su sed de venganza.
Reparto
Tobey Maguire — Spider-Man / Peter ParkerKirsten Dunst — Mary Jane WatsonJames Franco — New Goblin / Harry OsbornThomas Haden Church — Sandman / Flint MarkoTopher Grace — Venom / Eddie BrockBryce Dallas Howard — Gwen StacyRosemary Harris — May ParkerJ.K. Simmons — J. Jonah JamesonJames Cromwell — Captain StacyDylan Baker — Dr. Curt ConnorsTheresa Russell — Emma MarkoBill Nunn — Joseph 'Robbie' RobertsonBruce Campbell — Maître D'Elizabeth Banks — Miss BrantTed Raimi — HoffmanPerla Haney-Jardine — Penny MarkoWillem Dafoe — Green Goblin / Norman OsbornCliff Robertson — Ben ParkerIlya Baskin — Mr. DitkovitchMageina Tovah — UrsulaJohn Paxton — HousemanBecky Ann Baker — Mrs. StacyStan Lee — Man in Times SquareMichael Papajohn — Dennis Carradine / CarjackerJoe Manganiello — Flash ThompsonHal Fishman — AnchormanLucy Gordon — Jennifer DuganSteve Valentine — PhotographerTim Maculan — Play DirectorMarc Vann — Play ProducerJoe Bays — Jazz Club ManagerGregg Daniel — Precinct DetectiveRogelio T. Ramos — Emergency Room DoctorTimothy Patrick Quill — Crane OperatorMenachem Mendel Boymelgreen — Kid in Times SquareNasir Stewart — Kid in Times SquareAustin Hendrickson — Kid in Times SquareTaylor Hemhauser — Kid in Times SquareKathryn Bryding — Woman Outside TheaterJoe Virzi — Police DetectiveBill E. Rogers — New Jersey State PolicemanMichael Alexander — New Jersey State PolicemanApril Parker Jones — Test Site TechnicianEdward Padilla — Test Site TechnicianRobert Curtis Brown — Test Site TechnicianPaul Terrell Clayton — Test Site TechnicianCarolyn Neff — Test Site TechnicianChristina Cindrich — Test Site TechnicianSonya Maddox — ICU NurseAndre B. Blake — Crane Disaster Radio PolicemanDerrick 'Phoenix' Thomas — Cop at Crane DisasterJessi Collins — Mary Jane's ReplacementMichael McLaughlin — Boy at Key to the City CeremonyAnne Gartlan — CouncilwomanEmilio Rivera — Policeman at Sand TruckKeith Woulard — Policeman at Sand TruckReynaldo Gallegos — Armored Car DriverJim Coope — Newstand PatronDean Edwards — Newsstand PatronMargaret Laney — Newsstand PatronToni Wynne — Congratulatory Woman at Daily BugleAimee Miles — Coffee Shop WaitressTanya Bond — Jazz Club WaitressMark Kubr — Jazz Club BouncerEmma Raimi — Girl With CameraLorne Raimi — Boy at the Final BattleHenry Raimi — Boy at the Final BattleSamantha Ressler — Girl at the Final BattleAlan Cohn — Jazz Club MusicianDan Callahan — Jazz Club MusicianDaniel Cummings — Jazz Club MusicianRon King — Jazz Club MusicianCarol Chaikin — Jazz Club MusicianVance Hammond — Jazz Club MusicianFrank Anello — NYPD Officer (uncredited)Anya Avaeva — Model (uncredited)David Backus — Bucket Boy (uncredited)Tony Besson — Photoshoot Client (uncredited)Michael Ciesla — Photographer (uncredited)Irina Costa — Jazz Club Waitress (uncredited)John Crann — Theater Patron (uncredited)Crystal Marie Denha — Jazz Club Girl (uncredited)Amy V. Dewhurst — Columbia Grad Student (uncredited)Keith Fausnaught — Pedestrian (uncredited)Logan Fry — Automobile Driver (uncredited)Tony Galtieri — News Spectator (uncredited)Brian Hopson — News Reporter (uncredited)Andrew James Jones — Jazz Club Bouncer (uncredited)Natalie Jones — Girl at Key Ceremony (uncredited)Christopher Jude — Student (uncredited)Brittany Krall — ER Nurse (uncredited)Pierangeli Llinas — Woman in Court (uncredited)Bernadette Lords — British Publicist (uncredited)Natalie McNeil — Girl Screaming in Camaro (uncredited)Martha Millan — Oscorp Receptionist (uncredited)Michele-Nanette Miller — Girl in Times Square (uncredited)Claudia Katz Minnick — Robbie's Assistant (uncredited)Jen Oda — Beautiful Girl (uncredited)Anjelia Pelay — Beautiful Woman (uncredited)Nick Poltoranin — Police Officer (uncredited)Vanessa Reseland — Beautiful Woman (uncredited)La Rivers — Beautiful Woman (uncredited)Bria Roberts — Businesswoman (uncredited)Vanessa Ross — Sandman Victim (uncredited)Brenna Roth — Bad Girl (uncredited)Shade Rupe — City Hall Cheerer (uncredited)Abbey Skinner — Café Girl (uncredited)Daniel Shafer — Jazz Club Guest (uncredited)Kristin Somo — Jazz Club Patron (uncredited)Jennifer Sparks — Jazz Club Waitress (uncredited)Christopher Stadulis — NY Firefighter (uncredited)Aija Terauda — Model (uncredited)Evelyn Vaccaro — Beautiful Woman (uncredited)Nick Vlassopoulos — Bar Patron #5 (uncredited)Sincerely A. Ward — Model (uncredited)Jennifer Weston — ER Nurse (uncredited)Ray Wineteer — Spectator (uncredited)Emily Eckes — Beautiful Woman (uncredited)Craig 'Radio Man' Castaldo — Radioman (uncredited)